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Dental Professional Review

Fluoride or nano-hydroxyapatite? Both can help your enamel, but neither address the real problem.

Fluoride hardens your enamel. Nano-hydroxyapatite refills it. Neither one removes the bacteria doing the damage. Zero Pro is the first toothpaste built to do all three.


By Dr. Ben Winters, DDS/MS

Updated July 2026

"Most people don't know that cavities are caused by bacteria. In any other infection in your body, we'd get rid of the bacteria causing it. For your mouth, we only treated the symptoms, until now."

Here's An Analogy: Your Teeth Are Wood. The Bacteria Are Termites.

We've all heard it at some point: "Don't eat too much sugar, you'll get a cavity." But cavities aren't caused by sugar, at least not directly. They're caused by a bacteria called Strep mutans, and the easiest way to picture it is termites in wood.

S. mutans is an acid-producing bacterium that thrives on sugar. Over time, the acid it produces breaks down enamel. Once it breaks through the tooth's outer shell, it goes deeper, and you have a real problem on your hands.

For a hundred years, we had no way to remove that bacteria. There's a lot of good bacteria in your mouth too, and nothing could tell them apart. So instead of going after the termites, we focused on patching up the wood.

But that's damage control, not prevention.

Slowing Down The Termites: Fluoride vs. Nanohydroxyapatite (nHAp)

Fluoride Strengthens The Wood

That's what fluoride was built for. It hardens the outer shell of the tooth so the bugs have a harder time eating through it.

I want to be clear, because a lot of people online won't be: fluoride works. It works well. I still believe that.

But strengthening wood doesn't fix existing holes. They're still in there, and the termites are still chewing. Given enough time, they get through.

Nano-Hydroxyapatite Strengthens and Refills The Holes

This is the future of remineralization. nHAp is the same mineral your enamel is made of, so when the bugs eat a small hole, it fills the hole back in with your tooth's own material (hydroxyapatite).

At 10% and nano particle size, it's proven to support enamel at least as well as fluoride, if not better. Most brands use one to three percent, or use micro particles too large to get into the enamel tubules. That doesn't work. Zero and Zero Pro both use 10% nanohydroxyapatite to rebuild enamel.

But what if we could just get rid of those pesky termites to begin with?

The Targeted Takedown: BioFuse™ Removes The Termites

I spent over a million dollars and two years developing the world's first biotech toothpaste.

BioFuse™ Oil Matrix is the breakthrough that makes Zero Pro more advanced than any toothpaste before. In science terms, it's a nanolipid emulsion of activated plant oils engineered to recognize specific harmful bacteria. And in Zero Pro, we've gone after the two biggest pests: S. mutans, the cavity king, and P. gingivalis, the primary driver of gum disease.

When the oils find those bacteria, they bind to the cell wall, create holes in it, and the bacteria die. It's physical rather than chemical, which is why it leaves your good bacteria alive.

Get the bacteria down and keep it down, and your teeth get relief from the attackers.

Why Your Dentist Hasn't Mentioned nHAp or BioFuse™

A lot of dentists learned fluoride, fluoride, fluoride, and that was the end of the curriculum (trust me, I've been through dental school). Many have never read the newer nHAp studies and none have heard of a nanolipid emulsion like BioFuse™, because until now, there wasn't one in the industry.

That isn't a knock on your dentist. This is just how most industries work. The research moves fast and the practice catches up later.

Hear what Zero Pro users are saying:

"We use this for the whole family. I have gum disease and so does my husband. We put our 10-year-old on it so he won't get it, and my two-year-old is not there yet, but once she is okay with the taste, everybody will be using it. We will be customers for life."

★★★★★ Ash

"Best toothpaste I’ve ever tried!! It makes my teeth feel clean all day! The plaque that builds up during the day is now cut in half or more. I can’t believe how great my teeth feel. It also helped with the sensitivity! Wow!"

★★★★★ Amanda F.

"Good stuff. Had some brown and yellow spots on my teeth and it completely cleared them up. They are gone! I was worried cause the looked like the start of a cavity."

★★★★★ John R.

"I love the flavor and that it is not very overwhelming while still giving an amazing cleanse. This toothpaste does not burn compared to most toothpastes out there. After brushing, I feel like I just left the dentist's office, that's how clean my teeth feel. THANK YOU!"

★★★★★ Brittany G.

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